Venetian Casino, Nevada

With 7,117 rooms, the Venetian usually tops the list as the largest hotel in the USA. Several of the largest non-industrial buildings in the world are in Las Vegas, like the Palazzo Resort, with 6,948,980 square feet in a single structure with a footprint of over 2 million square feet. Elsewhere on the Strip are most of the ten largest hotels in the USA, including the MGM Grand (6,852 rooms).